Asthma and COPD

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Asthma and COPD

Asthma and COPD代写 Asthma and COPD are characterized by inflammation of bronchitis and periodic shortness in breathing and airflow limitation respectively.

Discuss the Mechanism of Action of Drugs Used to Treat Asthma And COPD  Asthma and COPD代写

Asthma and Obstructive Pulmonary Disease (COPD) are characterized by inflammation of bronchitis and periodic shortness in breathing and airflow limitation respectively. Drugs used in the treatment of asthma include bronchodilators and anti-inflammatory drugs (Olin, & Wechsler, 2014). Bronchodilators are used to ease the muscle and relax them. There are various types of bronchodilators including sympathomimetics and methylxanthines. On the other hand, anti-inflammatory drugs include corticosteroids, anti-IgE antibody, and mast cell stabilizers.

Asthma and COPD代写
Asthma and COPD代写

Mechanism of Drugs  Asthma and COPD代写

Sympathomimetics – It is a bronchodilator relaxer. Used to smoothen the bronchial muscle thought the activity of adenyl cyclase enzyme. The drug further creates stability of the bronchial mast cell (Olin, & Wechsler, 2014). For this activity, the drugs are used to treat acute asthma and long-term prophylaxis.

Methylxanthines – Theophylline and other derivatives antagonize the action of adenosine. As a result, the enzyme produces bronchodilation effects by blocking the effects of endogenous adenosine (Monteiro, Alves, Oliveira, & Silva, 2018). The phosphodiesterase inhibition and adenosine antagonism promote the smoothening of the airpath muscle relaxation and bronchodilation.

Corticosteroids – Used to treat inflammation in asthma by reducing the secretion of mucus through inhibition of secretagogue from macrophages (Barnes, 2013). It inhibits inflammatory response and interferes with chemotaxis. Asthma and COPD代写**范文

Anti-IgE antibody – The drug interferes with IgE. IgE responds to acute allergic reactions and chronic inflammations (Lommatzsch, Korn, Buhl, & Virchow, 2014).  The drug inhibits the activity of the IgE during the exposure to allergens.

 Mast cell stabilizers – The drug blocks mast-cell degranulation and stabilizes it thus inhibiting the release of histamine and other mediators. Once histamine is blocked, the response to allergic components is inhibited.

Asthma and COPD代写
Asthma and COPD代写

References  Asthma and COPD代写

Barnes, P. J. (2013). Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. Journal of Allergy and Clinical Immunology, 131(3), 636-645.

Lommatzsch, M., Korn, S., Buhl, R., & Virchow, J. C. (2014). Against all the odds: anti-IgE for intrinsic asthma?. Thorax, 69(1), 94-96.

Monteiro, J., Alves, M. G., Oliveira, P. F., & Silva, B. M. (2018). Pharmacological potential of methylxanthines: Retrospective analysis and future expectations. Critical reviews in food science and nutrition, 1-29.

Olin, J. T., & Wechsler, M. E. (2014). Asthma: pathogenesis and novel drugs for treatment. BMJ, 349, g5517.

 

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